Time Session
DAY 1
Monday
14 October 2019
ATTIRE: BUSINESS CASUAL
7:00-9:00 am
Koepelkerk
Foyer
Registration, Continental Breakfast
8:00-8:45 am
Koepelzaal
Sunrise Session
Kenneth Waterman, FreeThink Technologies (US)
ASAPprime® and the science of highly accelerated aging
8:45-8:50 am Conference Welcome
Kenneth Waterman, FreeThink Technologies (US)
Session I Accelerated Stability Modeling
8:50-8:55 am Session Chair: Alisa Waterman, FreeThink Technologies (US)
Introduction to Session
8:55-9:30 am Sara Vrielynck, Galapagos NV (Belgium)
Introducing ASAP into a new company
9:30-10:05 am Sabine Thielges, Novartis (Switzerland)
ASAP for parenteral formulation development – solution and lyophilisate
10:05-10:35 am
Koepelkerk
Balcony
Morning Break
10:35-11:10 am
Koepelzaal
Kenneth Waterman, FreeThink Technologies (US)
Accelerated stability modeling for difficult products: when nothing happens and when degradants degrade
11:10-11:45 am Els van Deventer-Troost, Janssen Pharmaceuticals (Belgium)
Experience of applying Arrhenius modeling and alternatives to adenoviruses
11:45-12:45 pm
Koepelkerk
Balcony
Lunch
12:45-1:20 pm
Koepelzaal

Hana Prokopcova, Janssen Pharmaceuticals (Belgium)
Status update on the predictive stability IQ working group for the modeling group

1:20-1:55 pm Elke Debie, Janssen Pharmaceuticals (Belgium)
Feedback from the Regulatory Sub-team of the Risk-based Predictive Stability IQ Group
1:55-2:30 pm

Susan Smith, AstraZeneca (UK)
Update from the IQ Lean Stability Working Group

2:30-3:00 pm
Koepelkerk
Balcony
Afternoon Break
3:00-3:35 pm
Koepelzaal
Graeme Horne, Summit Therapeutics (UK)
Stability Modeling of Amorphous Dispersions
3:35-4:10 pm Matjaz Boncina, University of Ljubljana (Slovenia)
Prediction of Stability of Biologics in Solution
Session II Forced Degradation and the Chemistry of Degradation
4:10-4:15 pm Session Chair: Sabine Thielges, Novartis (Switzerland)
Introduction to Session
4:15-4:50 pm Ash Ali, Lhasa Ltd (UK)
Zeneth knowledge-based system for the prediction of forced degradation of organic compounds
5:00 pm End of Day 1
5:00-7:00 pm
Upper Rooms/Koepelkerk Balcony
Reception
   

 
 

DAY 2
Tuesday
15 October 2019

 
7:00-9:00 am
Koepelkerk
Foyer
Continental Breakfast
Session II (cont.)
Koepelzaal
Forced Degradation and the Chemistry of Degradation
8:00-8:05 am Session Chair: Sabine Thielges, Novartis (Switzerland)
Introduction to Session
8:05-8:40 am Kausik Nanda, Merck (US)
Enrichment of relevant oxidative degradation products in pharmaceuticals with targeted chemoselective oxidation
8:40-9:15 am Steve Baertschi, Baertschi Consulting (US)
Drug photostability: the science and application of photo-produced reactive oxygen species
9:15-9:45 am
Koepelkerk
Balcony
Morning Break
9:45-10:20 am
Koepelzaal
David Elder (UK)
Mutagenic degradation products- prediction, assessment, control
Session III Packaging and Stability
10:20-10:25 am Session Chair: Kenneth Waterman, FreeThink Technologies (US)
Introduction to Session
10:25-11:00 am TBD
11:00-11:35 am Thomas Dries, Honeywell (Germany)
Protective blister packaging materials: Aclar
11:35-12:10 pm Daniel Stagnaro, Klöckner-Pentaplast (US)
Using finite element analysis to determine blister permeability from tooling design
12:10-1:10 pm
Koepelkerk
Balcony
Lunch
1:10-1:40 pm
Koepelkerk
Balcony
Poster Session
Session IV
Koepelzaal
Stability Science Frontiers
1:40-1:45 pm Session Chair: Steve Baertschi, Baertschi Consulting, LLC (US)
Introduction to Session
1:45-2:20 pm Garry Scrivens, Pfizer (UK)
Effect of drug load/particle size/surface area on degradation rates in solids
2:20-2:50 pm
Koepelkerk
Balcony
Afternoon Break
2:50-3:25 pm
Koepelzaal
Malin Suurkuusk, TA Instruments (Sweden)
Isothermal Microcalorimetry for Pharmaceutical Stability Assessment
3:25-4:00 pm Steven Brown, Warwick University (UK)
Solid-state NMR to understand pharmaceutical stability
4:00-4:10 pm Raffle Drawing
4:10-4:20 pm Conference Close