3rd Annual Conference 2017
3rd – 5th October 2017
Crowne Plaza Hotel – Blanchardstown, Dublin, Ireland

In Silico Characterization of Thermodynamic and Kinetic Stability of Amorphous Solid Dispersions

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In Silico Characterization of Thermodynamic and Kinetic Stability of Amorphous Solid Dispersions

In Silico Characterization of Thermodynamic and Kinetic Stability of Amorphous Solid Dispersions

Jeffrey S. Tan, Ph.D.
Senior Research Scientist, Eli Lilly and Company
Indianapolis, IN, USA

Amorphous solid dispersion is an important formulation platform for the delivery of poorly soluble drugs.  The solubility enhancement is achieved by disruption of the highly ordered crystalline lattice into a disordered amorphous state that is thermodynamically less stable.  This necessitates a comprehensive understanding of the thermodynamic and kinetic factors that can drive phase separation and ultimately crystallization of the amorphous material that will significantly impact in vivo performance of the drug product.  This presentation will discuss the application of drug-polymer binary phase diagrams as formulated by Flory-Huggins to assess thermodynamic stability and the use of accelerated stress-testing methodologies to assess crystallization kinetics of amorphous solid dispersions.