Understanding Importance of Water Sorption Isotherm Shape, Hysteresis, and Models on Pharmaceutical Materials

Understanding Importance of Water Sorption Isotherm Shape, Hysteresis, and Models on Pharmaceutical Materials

Daniel Burnett, Ph.D.
Director of Science Strategy, Surface Measurement Systems, Ltd.
Allentown, PA, USA

This educational seminar will focus on the interactions of water vapor and understanding physicochemical water sorption isotherms on pharmaceutical ingredients.  Moisture and/or humidity has significant importance for pharmaceutical and biopharmaceutical solid state R&D for drug discovery, pre-formulation and formulation development of active drug compounds, excipients, binders, and other materials.  In particular, practical examples of using the DVS for sorption mechanism determination and modeling, hydrate detection, amorphous phase detection and quantification, and vapor-induced transformations will be discussed.  Also, the combination of moisture sorption experiments with parallel techniques like video microscopy and Near-IR or Raman spectroscopy will be introduced including examples on pharmaceutically relevant materials.  Finally, diffusion and kinetic studies will highlight the application of moisture sorption techniques for studying moisture barrier and packaging applications.